Controlled release matrix tablets with HPMC KLV, HPMC K4M, HPMC K15M, and HPMC KM were formulated by wet (non-aqueous) granulation method. Surface plots of log viscosity with temperature (°C) and HPMC concentration (%, w/w) for HPMC a K LV, b K4M, c K15M and d KM. Download/Embed scientific diagram | Swelling index of HPMC K4M at different concentrations from publication: Influence of different grades and concentrations .

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This might probably be due to the non-significant influence of initial tablet matrix porosity on the initial release of soluble drug isoniazid once the minimum hardness was hmc 7.

The scores plot of the various formulations showed the presence of three clusters when the viscosity profiles of ternary melt suspensions were evaluated using PCA Fig. However, this was not observed. Comparative pharmacokinetics and pharmacodynamics of the rifamycin antibacterials.

Hypromellose – Wikipedia

Typical viscosity test will specify the following:. Its ingredients are globally recognized for performance, quality, and consistency. Polymer processing and rheology.

Each sample was transferred to the rheometer plate and excess removed with a spatula.

Chirality in Drug Design and Development. In the nomenclature of HPMC grades, an initial letter K, E, F identifies the different substitutions of methoxyl and hydroxypropyl groups in the polymer. This explained their similarity in viscosities among the grades as indicated in the surface plots.

Pharmacology of some slow-release preparations of isoniazid of potential use in intermittent treatment of tuberculosis. The authors express their sincere gratitude to Birla Institute of Technology and Science, Pilani, India for funding the project. Other research groups have reported similar results that the drug release rate decreased with increasing molecular weight for low-molecular-weight HPMCs and became independent of molecular weight for high-molecular-weight HPMCs 29 phmc When applied, a hypromellose solution acts to swell and absorb water, thereby expanding the thickness of the tear-film.


Although polymers have been studied over the years, polymer rheology is a difficult subject to comprehend 1.

Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M

Incorporation of antitubercular drug isoniazid in pharmaceutically accepted microemulsion: Pharmaceutical applications of solid dispersion systems. The formulated tablets were evaluated for their physical properties and in vitro release characteristics.

The reason for such observations would be difficult to explain, but hpkc possible explanation is as follows. Effect of microfluidization of heat-treated milk on rheology and sensory properties of reduced fat yoghurt.

4km bioavailability of rifampicin from fixed dose combination FDC formulations with isoniazid. Hiremath and Ranendra N.

Open in a separate window. Size distribution curves were plotted, and the median particle size, d 50was obtained. Amorphous-state characterization of efavirenz-polymer hot-melt extrusion systems for dissolution enhancement. An introduction to rheology. Design and study of rifampicin oral controlled release formulations. The low standard deviation values for all physical properties showed that there was excellent batch-to-batch reproducibility and absence of significant batch-to-batch variations.

Hypromellose in an aqueous solution, unlike methylcelluloseexhibits a thermal gelation property. Adv Colloid Interface Sci.

Controlled Release Hydrophilic Matrix Tablet Formulations of Isoniazid: Design and In Vitro Studies

From the in vitro studies, the formulations were found to be promising and could further be considered for in vivo bioavailability studies in suitable animal models or human volunteers to assess in vivo performance and bioavailability. The release profiles were further analyzed for f 2 factor values. Assessment of Molten Mixture Sprayability The sprayability of the molten mixture was assessed by evaluating its product yield obtained after the spray congealing process.


I—Formulation and in vitro evaluation. All the formulations within the same cluster had comparable viscosity profiles. In this study, the viscosity of the composite polymer melt suspension can be variable given that fibrous HPMC particles can have assorted orientations in the molten polymer.

In the later hours also, the release rates remained similar, as initial porosity has no effect on the release from the swollen tablet matrix. There are many fields of application for hypromellose, including: Oral controlled release formulations of rifampicin. Preparation and in vitro dissolution of isoniazid from ethylcellulose microcapsules.

Line plots of k4mm suspension viscosities with increasing temperature for a F-series, b E-series and c K-series. The Einstein coefficient depends on the geometry and orientation of the entities that make up the dispersed phase, e. Similarly, the drug release was observed to be higher in 0.